Myostatin : a negative regulator of muscle mass in vertebrates
Abstract
In livestock the double-muscled phenotype is well known and has been selected in certain breeds, in order to increase carcass yield . Even though the chromosomal location of the gene responsible for the double-muscled phenotype in cattle has been known for a long time, the gene was identified more recently with studies in mice. In fact, mutations present in the growth factor myostatin gene cause the doublemuscled phenotype. Myostatin is a negative regulator of muscle mass and plays a key role in muscle homeostasis. Myostatin also appears to be involved in the control of adipogenesis and osteogenesis. This review provides an update on the current state of the knowledge of myostatin and on the rational use of such knowledge in agronomy for meat production.
Attachments
No supporting information for this article##plugins.generic.statArticle.title##
Views: 12357
Most read articles by the same author(s)
- B. PICARD , C. JURIE , J.F. HOCQUETTE , L. LEFAUCHEUR , C. BERRI , M.J. DUCLOS , H. ALAMI-DURANTE, P.Y. RESCAN , Myofibre typing and ontogenesis in farm animal species , INRAE Productions Animales: Vol. 16 No. 2 (2003)
- I. CASSAR-MALEK, A. LISTRAT, B. PICARD, Hormonal regulation of muscle fibres characteristics : a review , INRAE Productions Animales: Vol. 11 No. 5 (1998)
- S. PRACHE, B. MARTIN, P. NOZIERE, E. ENGEL, J.M. BESLE, A. FERLAY, D. MICOL, A. CORNU, I. CASSAR-MALEK, D. ANDUEZA, Diet authentication in ruminants from the composition of their products and tissues , INRAE Productions Animales: Vol. 20 No. 4 (2007)
- M.P. ELLIES-OURY, Y. DURAND, A.E DELAVIGNE, B. PICARD, D. MICOL, R. DUMONT, Objectivation of the “grain of meat” notion and prospect of utilisation to evaluate the tenderness of Charolais beef meat , INRAE Productions Animales: Vol. 27 No. 5 (2014)
- J.F. HOCQUETTE, H. BOUDRA, I. CASSAR-MALEK, C. LEROUX, I. PICARD, I. SAVARY-AUZELOUX, L. BERNARD, A. CORNU, D. DURAND, A. FERLAY, D. GRUFFAT, D.P. MORGAVI, C. TERLOUW, Perspectives offertes par les approches en « omique » pour l’amélioration de la durabilité de l’élevage des herbivores , INRAE Productions Animales: Vol. 22 No. 5 (2009)
- B. PICARD, C. JURIE, I. CASSAR-MALEK, J.F. HOCQUETTE, (only in French) Typologie et ontogenèse des fibres musculaires chez le bovin , INRAE Productions Animales: Vol. 16 No. 2 (2003)
- C. JURIE, J. NÉDELEC, B. PICARD, (only in French) Production des anticorps monoclonaux spécifiques des chaînes lourdes de myosine , INRAE Productions Animales: Vol. 11 No. 2 (1998)
- B. PICARD, H. GAGNIERE, A. LISTRAT, J. ROBELIN, Y. GEAY, (only in French) Différenciation musculaire au cours du développement foetal et néonatal chez les bovins normaux et culards , INRAE Productions Animales: Vol. 9 No. 3 (1996)
- B. PICARD, M. DURIS, (only in French) Caractérisation des chaînes lourdes de myosine dans le muscle de bovin , INRAE Productions Animales: Vol. 11 No. 2 (1998)